Oral Chelation and Nutritional Replacement Therapy for Cardiovascular Disease

Oral Chelation and Nutritional Replacement Therapy for Cardiovascular Disease.

Our review of the scientific research which has been done on the ingredients in this product reveals the following results were obtained with these nutrients in regard to the above-mentioned factors.

A. LOWERING HIGH CHOLESTEROL

As almost everyone knows these days, high levels of fat in the blood (as measured by triglycerides and cholesterol) is one of the major indicators of cardiovascular problems. However, what most people do not know is that a large number of nutrients have been scientifically shown to lower cholesterol to normal levels. These nutrients all play a natural role in the body's handling of fats. However, due to a variety of reasons ranging from genetic differences and unbalanced diets to growing older, some people need more of these nutrients than they can get from their food. Supplementing with these nutrients has often produced amazing results.

MARINE LIPIDS
One of the most exciting development is the recent discovery that nutrients found in certain fish oils discovery that nutrients found in certain fish oils can have a major benefit in lowering cholesterol. These nutrients are known as Omega 3 fatty acids. Two of these, EPS (ecosapentaenoic acid) and DHA (docosahexaenoic acid) have proven to be especially beneficial. It was discovered that Greenland Eskimos and Japanese fishing village residents had very low levels of triglycerides and cholesterol. They almost never had heart attacks. Their blood contained high amounts of the EPA and DHA from their diet, high in cold-water fish Scientists found these fatty acids were very lipotropic- that is, they had the ability to dissolve and disperse cholesterol. Especially the dangerous LDL form, while protecting the benificial HDL form of cholesterol. Several groups of doctors have given these marine lipids to group of individuals with high cholesterol, and in each case there was a very significant improvement. At the University of Oregon, extensive studies have been going of for years with regard to marine lipids. Drs. Harris and Connors, along with others physicians, have found that when marine lipids are given as a nutritional supplement on a daily basis, there is a beneficial decline in both triglycerides and the harmful and dangerous LDL cholesterol. Dr. Connor has commented, "The higher these levels (cholesterol and triglycerides) are when the fish oil program started, usually the greater the fall."

VITAMINS TO LOWER CHOLESTEROL
One of the most discouraging things to heart patients is to cut out all their favorite foods because they contain cholesterol, only to find out after months of dieting that their cholesterol had hardly declined. At the University of Illinois, Dr. F.A. Kummerow tested a large number of patients on cholesterol restricted diets. He found only 10% of th cholesterol in the blood is contributed by cholesterol in the diet. A much more effective way to control cholesterol is to give supplements of nutrients which are required by the liver for proper metabolism of carbohydrates, fats, and cholesterol.

Among the most significant of these is a little known B vitamin called inositol. Without sufficient quantities of inositol, the liver is unable to efficiently convert fats and carbohydrates to energy- thus they end up as fat in the blood. Drs W.C.Felch and L.B. Dotti took a group of diabetic patients with elevated triglycerides and cholesterol levels and gave them insitol supplements. Within a few weeks these patients had their triglycerides and cholesterol return to normal. Reporting in the American Heart Journal, Drs. Leinwand and Moore describrd how they gave supplements of inositol to a group of heart patients with elevated cholesterol and triglyceride levels.

In a few weeks on inositol supplements, there was a substantial drop in these elevated levels to normal ranges. Choline is another little-known B vitamin that works with insitol in the liver to control fat metabolism. Drs. Morrison and Gonzales gave supplements of choline to a group of 115 cardiovascular patients, and placebo to a matched group of 115 others. There was a substantial decline in the level of triglycerides and cholesterol, but only in those receiving the choline. However, most importantly, over the next three years there was a 60% decline in the death rate for those taking the choline- compared to the placebo group.

Scientists now know the importance of these vitamins to the liver in manufacturing lecithin- a very powerful fat dissolving detergent which reduces blood fat levels. As far back as 1958, Dr. T.D. Labeski had demonstrated that by supplementing the diet with both choline and inositol, the blood level of lecithin would rise followed by a decline in triglycerides and cholesterol. In just two months, patients who had just had heart attacks had their cholesterol and triglycerides brought to normal using only choline and inositol.

METHIONINE, VITAMIN B-6 AND MAGNESIUM
It is well known among scientists that methionine is essential to proper fat metabolism in the liver. One reason for this that it converted to choline and then lecithin. Drs. Mann and Andrus of Harvard University demonstrated the importance of methionine by feeding these monkeys a diet that was complete in all respects except in the amino acid methionine. The monkeys soon developed high cholesterol and aherosclerosis. However, methionine cannot be adequately converted to choline or lecithin unless there is a sufficient amount of vitamin B-6. research by Dr. K. McCully at Harvard Medical School established that without adequate vitamin B-6, methionine would be converted to homocysteine. This is a powerfull free radical which damages arterial walls, resulting in plaque formation. Many scientists feel that most Americans are very deficient in this important nutrient. This may be a major cause in the formation of atherosclerosis. However, the liver still cannot make lecithin unless there is also enough magnesium present. Magnesium is essential for the utilization of amino acids and the lowering of blood lipid levels. Yet when they were given magnesium supplements, within just one month many of these elevated cholesterol levels fell dramatically. In 1984 Dr. W. H. Davis and associates gave magnesium supplements to a group of men with abnormally low levels of the protective HDL cholesterol. Within weeks this magnesium supplement had elevated the protective HDL level.

CALCIUM AND CHROMIUM
In 1972 Dr. M. L. Biembaum and associates gave large groups of patients with elevated serum (blood) cholesterol a daily supplement of calcium. After a year of calcium supplements their serum cholesterol fell by an average of 25%. Chromium is another mineral which has shown the ability to lower serum cholesterol. In 1981 Drs. Railes and Albrink gave daily 200 mcg. supplements of chromium to patients with elevated serum triglycerides and cholesterol. Their elevated levels soon returned to normal along with an increase in the beneficial and protective HDL cholesterol, and an improvement in their tolerance to glucose.

NIACIN AND VITAMIN C
In 1975 the Coronary Drug Project Research Group of the American Medical Association reported that one of the most effective agents for lowering cholesterol was the vitamin B niacin. They found that it also reduced the rate of reoccurring heart attacks by 29%. Dr. Grundy and associates reported the results of their research with niacin in 1981. They found niacin produced a 22% reduction of serum cholesterol and a 52% reduction in triglycerides. In 1976 Drs. Turly, West, and Horton demonstrated that when Vitamin C is present in the blood serum it stimulates the release and activation of plasma lipoprotein lipase which promotes the breakdown of serum triglycerides. Research in 1979 by Dr. Emil Ginter and associates has revealed that a liver enzyme which is responsible for the conversion of excess blood cholesterol to bile for elimination, is vitamin C dependent. Without adequate vitamin C in the liver, cholesterol soon accumulates in the blood. These discoveries explain why by 1970 three different research groups had found that the serum cholesterol level goes up and down with the intake of vitamin C. In 1971 Dr. C.R. Spittle, a Vitamin C researcher, wrote: "Atherosclerosis is a long-term deficiency of Vitamin C which permits cholesterol to build in the arterial system and results in changes in other fractions of fats." Nobel Prize winning scientists, Dr. Linus Pauling tells how changes were reversed. "...a high level of vitamin C increases the amount of high density and decreases the amount of low density lipoprotein cholesterol. Both of these changes help to protect against cardiovascular disease."

GARLIC AND GINGER
Although revered by grandmothers from the "old country" for years, it was not until 1977 that Drs. Bordia, Josh, and Sanadhya scientifically demonstrated that daily garlic intake lowers the harmful LDL cholesterol and triglycerides, while elevating the beneficial and protective HDL cholesterol. In 1978 Dr. S Gujaral and associates found that the old-fashioned herb Ginger is very effective in lowering serum cholesterol if taken on a daily basis.

L-CARNITINE
One of the most exciting discoveries in the area of improving cardiovascular health from a nutritional point of view is L-Carnitine. This protein structure is made from two amino acids- lysine and methionine. Dr J.D. Hulse and associates studied L-Carnitine in 1978 and found that vitamin B-6 and Niacin were required in order to form it, as well as magnesium and vitamin C in large amount. The lack of vitamin C in scurvy results in high levels of blood fat, and this may be due to the body's inability to produce carnitine. However, Dr. P. R. Borum discovered in 1981 that not everyone has the same ability to manufacture this amino acid substance. He found that some individuals have such a limited ability to produce carnitine that this predisposes them to developing high blood fats and cardiovascular problems. carnitine is found in its largest quantities in the heart, liver, testes, and muscles. In the cells of these tissues it combines with free fatty acids to form fatty acyl carnitine. In 1983 Dr. Borum found that carnitine is absolutely essential for the transportation of fatty acids across the membrane and into the mitochondria. These are energy producing factories of the cell. These are energy factories of cell.

There these fatty acids oxidized (burned) to release energy. As Dr. Hans Neiper has pointed out, the heart muscles obtain more than half of its energy by burning fatty acids, while skeletal muscle depends almost entirely on glucose. Thus, a deficiency of carnitine greatly reduces the primary source of energy for the heart. Such a deficiency can rapidly lead to angina and cardiac insufficiency. In 1977 Dr. J. Bremer found that when carnitine was deficient in the heart, fatty acids began accumulating in heart cells, then the heart tissues and finally they backed into the blood.

This raised the blood levels of triglycerides and cholesterol. The following year Dr. J.D. Folts and teams found that when fatty acids remained in cardiac cells and tissues because of a lack of carnitine to transport it into the mitochondria, the fatty acids developed oxidative derivatives which became extremely damaging to the heart muscle cells. Dr. M. Baroldi,a phologist who worked with famous heart surgeon Dr. Dention Cooley and the U.S. Army Pathological Institute in Washington, DC, has collected a large amount of evidence that shows most heart attacks occur not because of blocked arteries, but because heart muscles have developed abnormal chemistry and die -thus leading to heart attack and death. Thus carnitine supplements which improve heart muscles cell chemistry would seem to be a major step forward in reversing this degeneration and death of heart muscle cells, thus preventing heart attacks. As far back as 1975 Drs. J.D.McGarry and W.D. Foster were giving cardiac patients supplements of carnitine. They found that fat metabolism was increased and that triglycerides and cholesterol levels fell dramatically. The following year Dr. J.H. Thomsen and associates gave carnitine supplements to cardiac patients and found that it improved the ability of the heart to withstand stress tests. That same year Dr. Maebashi and team reported in the Lancet that 8 weeks of carnitine supplements dropped the triglyceride levels of a cardiac patient from 840 to 186%. In 1982 Drs. Rossi ans Siliprandi found that carditine supplements significantly elevated the protective HDL level. Dr. P. Pola and associate selected two groups of patients, one group with high triglycerides, and one with high cholesterol. They gave them supplements of carnitine for 40 days. Both groups had dramatic declines in both their triglycerides and their cholesterol. The data presented here makes it obvious that carnitine is a nutrient which is very important in the body's ability to metabolize fats, particular in the heart muscle cells. L-Carnitine is a very expensive supplement, and its inclusion in the formula at a clinically effective levels of 750 mg. per day make this formula the most nutritionally supportive formula for healthy cardiovascular tissue yet developed.

NUTRIENTS WORKING TOGETHER
We have just reviewed the scientific evidence which shows that each of these nutrients is indvidually capable of helping the body raise the benificial HDL and lowering the triglycerides. These nutrients are:

All of these beneficial nutrients have been included in the "Lifetime" Formula at clinically effective levels. In this way they can work synergistically together, supporting and reinforcing each other - thus greatly amplifying their powerful nutritional benifits.

B. ELIMINATING PLAQUE AND ATHEROSCLEROSIS

DANEROUS FREE RADICALS
Most of the molecules in our body and natural foods are either electronically balanced or carry ionic charge which allows them to join constructively withother molecules. This is the basis for biochemistry that makes life possible. However, most of the chemicals which are forien to our body and our food readily break into molecules which carry a dangerous and damaging electronical charge. These molecules are called "free radicals."Prior to the year 1900, the average American had very little exposure to chemicals in their food, water, or environment which would break into free radicals. Americans also had almost no heart attacks prior to 1900. Today there are over 3,000 chemicals being added to our food as flavors, colors, emulsifiers, extenders, preservatives, ect. Each of these is a potential free radiacal. Not to mention chlorine and fluorine which has been added to our water supply, both of which are sources of powerful free radicals. In his book, Coronaries-Cholesterol-Chlorine, Dr. Joseph Price has pointed out the close relationship in the rise of chlorinated water to rise in heart attacks.

NATURAL PROTECTION
People on a simple natural diet generally get all the nutrients they need to control their biochemistryand live long and fruitful lives. Their body is equippedwith enough of a special group of enzymes to neutralize free radicals as they develop. However, on today's diet high in refined and processed foods, loaded with chemicals and depleted of many key nutrients, it is a different story. Free radicals released in the body at such a high rate, and at such an early age, the body's ability to control all of them is soon depleted, and much damage begins to occur.

HOW A PLAQUE FORMS
In 1973 Dr. Earl P. Benditt and associates at the University of Washington School of Medicine discovered how arterial plaques form. They found that when free radical molecules come in contact with cells that line the inside of the artery, they damage the cell wall. later other free radicals enter through this damaged area to the inner partsof the cell where they cause additional damage. Eventually the cell is so altered it becomes abnormal and begins to divide and multiply rapidly.

These plaque cells are largly collagen which makes them very though. As the inner cells of this plaque begin to grow old and degenerate, they yeild an above-average amount of cholesterol. These cells also have an abnormal energy metabolism. Dr. Benditt and team found that these plaque cells are very similar to tumor cells. While this whole process has been going on, these plaque cells have been releasing a prostaglandin called thromboxane or PG2. This causes fibers to form over the top of the plaque, resulting in red blood cells and platelets adhering to the plaque. Even 20 year old men were found to have thousands of tiny plaques forming in their arteries when autopsies were performing during the Vietnam war. Older people often have their arteries totally by these tough, fibrous, cholesterol-laden plaques. This conditions is known as atherosclerosis.

NUTRIENTS TO PREVENT ATHEROSCLEROSIS
Seven nutrients have been found to be very effective at neutralizing free radicals before they can cause harm in the body. Supplements of these nutrients have been able to halt free radical activity and prevent plaque formation. The forthcoming research data will reveal the role of some of these nutrients in body chemistry that prevents atherosclerosis.

VITAMIN E
At the University of California, Davis, Dr. A.L. Tappel has established that as an oil-soluble vitamin, vitamin E becomes part of the lipid matrix in the cell wall, and prevents free radicals from burning holes in it. Since the first step in the development of plaque and atherosclerosis is created by the free radical attack of our arterial lining, vitamin E's prevention of this is very important to us. At the University of Puget Sound, Dr. J. Bland found that when exposed to free radicals of ultra violet light and air, the walls of red blood cells broke down. Within 13 hours 100% of the red blood cells had totally disintegrated. Yet when these same volunteers supplemented their diet with Vitamin E, only 5% of their red blood cells had disintegrated after exposure to the same free radicals. It will be recalled that arterial plaque cells are developed after free radical attack and are very much like cancer cells. Dr. Denham Harman, University of Nebraska School of Medicine, conducted an experiment in which he exposed the skin of mice to cancer-causing chemicals. Then he fed them various nutrients to see which ones offered the greatest protection against the development of abnormal cancer cells. He found that vitamin C gave 32% protection, selenium 42%, but vitamin E gave a whopping 63% protection.

Vitamin E is also found in heavy concentration in the wall of mitochondria where energy is manufactured in the cell. Without adequate vitamin E, oxygen escapes during the energy-releasing process. This increases the body's need for oxygen. Drs. Houchin and Mattill were able to demonstrate this by measuring muscle tissue's oxygen requirements before and after supplementation with vitamin E.

They found that within 24 hours after vitamin E supplements, the oxygen requirement dropped by 60 to 71%. Imagine what this would mean to an oxygen-starved heart. In 1963 Dr. Boyd and co-workers took X-rays of the arteries of people with long standing atherosclerosis, before, during, and after supplementation with vitamin E. The X-rays clearly showed the gradual clearing of calcium and the dilation of the arteries over a period of a few months. In 1968 Dr. Kurk Haeger did a controlled double blind study of people with restricted blood flow due to narrow atherosclerotic arteries.

After a few months, those on the placebo showed a continued deterioration of their blood flow. Those on the vitamin E showed a dramtic increase in their blood flow as measured by objective scientific instruments. In 1980, Dr. J.L.Machlin established that a large amount of published and confirmed scientific research had proven vitamin E supplements will definitely prevent and reverse atherosclerotic plaque, and even open up atherosclerotic narrowed arteries over a period of months. Rabbits are highly prone to develop high cholesterol and plaques when fed a fatty diet.

However, Drs. Wilson, Middleton, and Sun found that when rabbits on this atherogenic diet were also given vitamin E supplements, they were protected from free radical damage and did not develop atherosclerotic plaques. Drs. Cheraskin and Ringsdorf at the University of Alabama School of Medicine and Dentistry, studied a group of middle aged male heart attack victims for a period of one year. They found that those in the group who had a below average intake of vitamin E had a deterioration of their condition comparable to what is considered average for their age and condition.

However, those who were on vitamin E supplements, and had an average intake, experienced a 30% reduction in the severity of their condition. From thses studies we can easily conclude that vitamin E is very important in reversing atherosclerotic plaque formation and in protecting our body from the free radical attack.

SELENIUM
Science has shown us that this little known element may very well be the most important mineral to health of the heart and vascular system. A powerful free radical scavenger in its own right, it also serves as the heart of glutathione peroxidase, one of the two most important enzymes our body uses to control free radicals. Dr. J.T. Rotruck did a study on animal tissue levels of both selenium and the enzyme glutathione peroxidase. He found the lower selenium levels were, the lower were the levels of this all important enzyme. Dr. A.M. Novi has conducted many experiment which have shown that when selenium-activated glutathione is low, free radical damage to cell is massive, and leads to the development of cancer cells- such as those that make up plaque in their arteries.

The impact of a lack of selenium on the blood vessels was noticed among animals where it has been found to produce abnormalities in virtually evey specie, from chicken and turkey, through swine, lambs, and cattle. It was estimated by the U.S. Dept. of Agriculture that American farmers lost over 100 million dollars in 1973 due to selenium deficiencies on the health of farm animals. Drs. Schaamberger and C. Willis found that those between the ages of 55 and 64 living in selenium rich areas were protected with a heart disease rate of 67% BELOW the national average, while those living in selenium poor areas had a heart disease rate of 22% ABOVE the national average. Dr. J.E. Vincent at Erasmus University, Rotterdam, Netherlands is a world recognized authority on prostaglandins which regulate the blood pressure. Their manufacture is dependent upon the availability of selenium. He found that when selenium is low, these prostaglandins will only be manufactured up to a certain point, then as incomplete substances they willenter the blood stream.

These incomplete prostaglandins now cause degenerative lesions, plaque formation platelet clumping, and an elevation of blood pressure. Dr. James Aiken of the Upjohn Laboratotie has discovered a kidney prostaglandin which regulates blood pressure. Dr. N. Larsen in Vienn, Austria confirmed this discovery and found, like Dr. Vincent in the Netherlands, that the production of this prostaglandin is selenium dependant. He found that the blood from patients with high blood pressure was always low in selenium compared to the level of selenium in the blood of healthy people. Dr. Johan Borksten studied the heart attack rate among the people of Finland and compared it to the soil and water levels of selenium in the areas where they lived.

He found that those who lived in selenium richer areas had a heart attack rate of 1 per 1,730 people, while those living in low selenium areas had a heart attack rate of 1 per every 224 people. A rather profound indictment of the importance of selenium to the cardiovascular system. Another veryimportant study on selenium was done in Finland. There a research team under the direction of Dr. J. T. Salonen collected and froze the blood of 11,000 peolpe who had no outward sign of illness. All werethought to be healthy. Over the next 10 years 367 of these people died from heart attacks or other heart disease. They were carfully matched to other people from this same group who still appeared to be healthy. They were matched, according to age, sex, blood pressure, and cholesterol. The frozen blood of all these peolpe was then thawed and compaed for differences. The most glaring difference turened out to be the difference in their selenium levels.

Those who developed fatal heart conditions had much lower selenium levels in thier blood than did those who remained healthy. It was also found that those who had a selenium level below 45 mcg. per liter of blood, had a death rate due to cardiovascular incidents 300% ABOVE those who had selenium levels above 45 mcg. Including this examination of selenium, we should point out that when selenium and vitamin E were mixed together in one tablet and given to cardiac patients in Mexico City who had severe reoccurring angina pectoris, Dr. J. Willalon reported that it was 92% effective in eliminating or reducing angiana attacks and improved both the electrocardiogram and the capacity of the patient to do work. All of this evidence makes it more that just moderately clear that if we wish to have healthy hearts, we must have an adequate daily intake of Vitamin E and Selenium.

ASCORBYL PALMITATE
Lipids (fats) when altered by free radicals become rancid. This happens inside our body in the same way it does in our kitchen. Since the walls of our cells, including arterial cells and red blood cells, are filled with lipids, it is our great advantage to protect them. Tests by Eastman Food Labratories have shown that soybean oi, a lipid like those in our body, will become rancid in seven days when unprotected by a free radical scavenger. The addition of just noe-tenth of one percent of vitamin C as ascorbyl palminate will allow soybean oil to remain unaltered for more than twice as long (16 days) before being altered by the free radicals. Although very expensive, the "LIFETIME" formula contains a significant amount of this powerful protector of lipids. in the blood stream ascorbyl palminate may be able to protect the lipid-filled membranes of the arterial cells from the plaque-generating free radicals with which they come in contact, as readily as it protects soybean oil.

CHROMIUM
Chromium is another element that is important to the cardiovacular system. Drs. Schroeder, Nason, and Tipton did a study on chromium and found that when man or animals were deficient, there is a higher rate of atherosclerosis and death. A study completed in Israel in 1980 by Drs. A.S.Abraham and coworkers found that when rabbits develop clogged arteries due to a high fat diet, chromium will allow these occlusions to be dissolved. A study completed in 1978 by Dr. H.A. Newman and associates found that patients reporting to hospitals with coronary artery disease had chromium levels in thier blood serum several time lower than those who reported for other conditions. In 1984 this study was repeated by Dr. M. Simonoff and team, this time using blood plasma instead of serum. It was again discovered that coronary patients had chromium levels several times lower than non-coronary patients. These facts definetly indicate that chromium deficiency plays a major role in the generation of atherosclerosis.

VITAMIN C
We have previously mentioned the tremendous benefits of Vitamin C in its role of raising the beneficial HDL and lowering the harmful LDL cholesterol. However, vitamin C offers additional benefits to the cardiovascular system by aslo acting as a neutralizer of free radicals before they can attack our arteries creating atherosclerosis. In 1972 Dr. M.L. Riccitelli of the Yale School of Medicine states that evidence has existed since 1949 that vitamin C will prevent atherosclerosis. He cited the work of Dr. J. B. Duguid in 1949 that demonstraited the development of atherosclerosis in guinea pigs simply by reducing their dietary intake of Vitamin C. Researchers such as Dr. Emil Ginter of Czechoslovakia, Dr. G.C. Willis of Canada, Dr. C.S. Leslie of England, Dr. K.R. Sebrov in Russia, and in America R.O. Mummo at Rutgers University have all demonstrated that when vitamin C levels are elevated, that not only does serum cholesterol drop but that in both man and animals atherosclerotic plaques general begin to disappear.

Using nothing but supplements of Vitamin C, Drs. Krumdiek and Butterworkin 1974 obtained a substantial reduction of plaque in 60%of the patients receiving the vitamin C in less than a year, while none of the placebo group experienced plaque reduction. Writing in the British Medical Journal, The Lancent, Dr. E.G. Knox published the results of a study showing that high coronary death rates in areas of England with low vitamin C intake, while areas with high vitamin C intake had a much lower coronary death rate. Perhaps one of the most amazing experiments by Dr. Sir Hans Krebs in England in 1946 when he was able to induce heart attacks in healthy volunteers between the ages of 20 and 30, simply by placing them on a diet dificient in Vitamin C.

The importance of vitamin C to a health cardiovascular system is born out by the research in Russia, carried out by Dr. Zaitsev and coworkers in 1964. They fed radioactive cholesterol to guinea pigs, then using a Geiger counter, determined how there cholesterol was used. guinea pigs. Guinea pigs, like man, require vitamin C in thier diet. Those not receiving enough vitamin C deposited the cholesterol in their aora (the main artrey from the heart). Whereas those who received adequate vitamin C deposited the cholesterol in the liver, where with the use of vitamin C it was converted to bile and excreated from the body, and in the adrenal glands, where with the use of vitamin C it was coverted to hormones.

REVERSING ATHEROSCLEROSIS
While there is no nutrient which can either prevent or reverse plaque formation or atherosclerosis, the human body can. It can, when it is adequately supplied with the raw materials which allow it to do so. Five of the most powerful raw materials to support the body in this activity are Vitamin E, selenium, chromium, ascorbyyl palmitate, and Vitamin C. These are the most powerful nutrients available for the protection of the cardiovascular system against the damaging effects of free radicals so prevalent in our modern world. Each of these is included in the "LIFETIME" Formula at biologically effective levels where they are able to support and reinforce each other.

In addition, they are supported in the "LIFETIME" Formula by a full compliment of less active free radical extinguishers- zink, copper, maganese, cystine, methionine, glutamine, vitamin A, and beta-carotene. This entire cast of nutrients is able to provide a basis of nutritional support to the cardiovascular system, from which it may draw to protect itself from free radical degradation, and thus maintain cardiovascular integrity, as well as provide broad spectrum nutritional support for the entire body.

C. PREVENTING CLOTS & THINNING THE BLOOD

PREVENTING STICKY BLOOD
The lining of the arteries is only one layer thick. Part of the duties of thecells that make up this lining is the manufacture if a substance known as prostaglandin 1, also called prostacyclin or PG1 for short. Thsi substance keeps the walls of the arteries slippery so that platelets and red blood cells do not stick to the artery walls, or to each other. This is very important because as Dr. Maclouf and coworkers have demonstrated, even a small clot releases thromboxane. This is an inflammatory chemical that irritates the artery walls, stimulating fibrinogen to create fibers, and causes other platlets and red blood cells to become sticky and adhere to each other-thus promoting atherosclerosis and blood clots, which may lead to strokes and heart attacks. Obviously, it is important to prvent this. While the taking of aspirin will thin the blood and prevent blood clots, it also creates a toxic effect upon the liver, inhibits normal clottong of injuries, and there is a danger of stomach hemorrhages. Just as effective at preventing clots, but without the negative side effects, is a whole series of nutrients which can also do a lot more for your body than just thin your blood and prevent clots. we shall examine a few of these.

BROMELAIN
Bromelain is a complex of proteolytic enzymes found in the stem of green pineapple. One of the amazing properties of bromelain is that unlike other proteolytic enzymes, this one has the ability to cross the intestinal wall and enter the blood stream. Several studies including one by Drs. Miller and Oper show that up to 40% of orally ingested bromelain enters the blood. Once in the blood, Drs. Ako and coworkers found that bromelain activates a plasmin- a natural blood substance which dissolves the fibers found in atherosclerotic plaques. In addition Drs. Schaffer and Adelman found in 1985 that bromelain-activated plasmin prevents platelets from abnormal clotting. This is achieved by inhibiting the production of thromboxane-the irritating prostaglandin which causes blood clots. It was found by Drs. Taussig and Nieper that a daily dose of 60 to 160mg. of bromelain is sufficient to cleanse the arteries of blood clots when given on a long-term basis. The "LIFETIME" Formula provides 200 mg. per day, thus providing a nutritionally effective level.

GARLIC AND GINGER
As has been previously mentioned, free radical activation of thromboxane leads to fiber formation, platelets aggregation, and clotting. All key factors in the formation of atherosclerotic plaque. The herb garlic contains a number of sulfur-rich compounds which Drs. Norwell and Tarr found in 1983 inhibit an enzyme called cyclo-oxygenase. It is this enzyme that is responsible for the release of damaging thromboxane. By inhibiting this enzyme, garlic prevents the formation of atherosclerotic fibers and clots. As dramatic as garlic is, the herb ginger is even better. Ginger contains three different sesquiterpenes compounds which Dr. K Sirvastava found in 1984 were significantly better at inhititing thromboxane production and platelet clotting than was garlic.

VITAMIN C AND E
It was found by Drs. Ross and Vogel in 1978 that vitamin C is capable of preventing platelets from forming abnormal blood clots, while at the same time not interfering with normal wound clotting time Dr. C.S. Leslie conducted an experiment in which hospitalized clot-prone patients were divided into two groups. One received a placebo and the other group received one gram of vitamin C per day. A comparison demonstrated that clot incidence among the vitamin C group was just half of the placebo group. In 1949 Dr. Alton Ochsner, at the time a famous American surgeon, discovered that by giving his surgical patients vitamin E supplements, he could prevent the blood clots that usually follow surgery. During the early 1970's a team of Swedish researchers led by dr. Korsn Bengsten conducted four separate studies using vitamin E. In 1975 they published their results showing that vitamin E made the blood thinner and prevented abnormal blood clots, while not inhibiting normal wound healing time. In 1981 a review of the research wound healing time. In 1981 a review of the research showing vitamin E prevent abnormal blood clots was verified and published by the highly respected New England Journal of Medicine.

EPA-VITAMIN B-6 & BIOFLAVONOIDS
In 1984 it was shown by a British research team led by Dr. B.E. Woodcock that EPA found in marine lipids was capable of inhibiting the release of thromboxane by promoting the syntheses of prostacycin. This allows the platelets to remain slippery and prevents abnormal clotting of the blood. Dr. S.C. Lam headed an American research team which discovered that high blood levels of vitamin B-6 also inhibited platelets from abnormal clotting. Dr. R.C. Robins at the University of Florida has conducted a number of experiments comparing various bioflavonoid compounds to the known anti-adhesive effect of powerful drug heparin. This drug is usually injected in medical emergenceis to prevent blood clots. Yet Dr. Robins found that the citrus bioflavonoids had superior anti-thrombic ability to prevent clots that heparin. Dr. Robbins has also made another amazing discovery with regard to bioflavonoids. They lower elevated hematocrit to normal without lowering a normal one. The hematocrit is the amount of red blood cells compared to the overall blood volume. It was the famous Framinham Study that established a high hematocrit as an indicator of impending heart attack or stroke. However, the daily intake of bioflavonoids can lower the hematocrit to normal. 96

Anti-Clotting Synergy

We have reviewed the scientific finding on eight totally natural substances which reveals each of them has the ability to dramatically inhibit platelets and red blood cells from forming abnormal clots. An ability that exceeds even that of the most potent anti-clotting drugs. Not only is this important from the standpoint of preventing sudden death due to heart attacks, strokes, and embolisms, it is also important from the standpoint of preventing plaques and artherosclerosis. In 1978 it was found by Drs Ross and Vogel that when platelets clump together they release a powerful mitogenic polypeptide. The polypeptide causes DNA synthesis and the proliferation of any cell where the platelets adhere along the arterial walls. 73 Thus the clots become extremely atherosclerogenic. The eight natural substance reviewed here help the body prevent this in a totally natural and beneficial way. With all eight of them working together at a nutritionally effective level, such an unprecedented beneficial effects is compounded by the synergy of reinforcement to reach an unprecedented level of support for both the cardiovascular system, as well as the entire human body an a maintenance basis.

Supporting the Cardiovascular System

The following nutrients in the "LIFETIME" Formula have all been found to provide specific nutritional support for the cardiovascular system.

Vitamin A Supplements have been found to be highly beneficial in the prevention of heart disease. Drs Ross and Campbell conducted an experiment in which 136 patients were given 24,000 IU of vitamin A and 3,000 IU of vitamin D per day. Another 271 patients received only a placebo. At the end of 5-12 years, only 8 people of the 136 receiving the A & D supplements developed coronary heart disease, while 43 of the 271 without the supplement became afflicted. The incidence of heart disease without vitamin A & D was 25 % greater than those who received it.83

Beta Carotene is a very active single-oxygen quencher and a good free radical scavenger, which prevent lipid peroxidation (Fat rancidity). Dr. J. A. Olson discovered it is transported through the blood in LDL cholesterol where it helps reduce its harmful oxidative effects on the arterial walls.84

THIAMIN - the first member of the B-complex family has been found to be a vitally important nutrient to the heart. Numerous animal experiments have demonstrated this relationship. One study consisted of a thiamin analysis of cardiac tissue from 10 people who died from heart attacks and 10 who had died due to other causes. The thiamin content of heart attack victims averaged 45% of that of non-heart attack victims.85

Ribofalvin- the second B-vitamin was found in 1981 at the University of Alabama School of Medicine to be vitally critical for the production of glutathione, one of the two most important free radical controlling enzymes manufactured by the body. Glutathione guards the lining of the blood vessels, the red blood cells, and the lens of the eye from free radical attack. Drs. Skalka and Prchal found that when riboflavin becomes to low, cataracts form in the eye, red blood cells disintegrate, and arterial plaques form rapidly.86

PANTOTHRNIC ACID-(B-5) is known as the "stress vitamin" because of its role in supporting the adrenal glands in producing stress hormones. It is also major component of the important molecule C0enzyme A, which is vital to the creation of energy from carbohydrates and fats. A lack of pantothenic acid had been shown to lead to a rapid heart beat. 87

FOLIC ACID is a little known vitamin important in a wide variety of functions, which is often deficient in many people. Dr. T.L. Kopjas did a study with 17 elderly patients with serve atherosclerosis. Giving them supplements of folic acid, their small arteries dilated enabling blood to flow. Their circulation so improved that vision improved and leg ulcers healed.88

BIOTIN is a vitamin involved in energy pathways and lipid metabolism. The very physically active and the elderly frequently demonstrate deficiencies. The Medical Journal Artery reported in 1980 that supplements of this vitamin to the elderly resulted in a decline of their elevated blood lipids. 89

PABA is a vitamin best known for its ability to protect proteins from cross-linking, and therefore a favorite sun-screen. However, in the 1977 Dr. B. Vessby at the University of Uppsala in Sweden gave PABA supplement in a double-blind cross-over study to individuals with elevated cholesterol. The PABA lowered both cholesterol and triglycerides without lowering HDL.90

CHONDROITIN SULFATE a & MUCOPOLYSACCARIDES - Dr. A. Verlangieri at Rutgers University discovered that when atherosclerosis developed, something was lost from the arterial wall. He found that cholesterol attached itself only to those areas where the substance was missing. He learned that the missing substance was Chondroitin Sulfate, which disappears when vitamin C gets low. Meanwhile, Dr. L. Morrison began giving atherosclerotic patients supplements of Chondroitin Sulfate extracted from calf trachea. Dr. Morrison reported an 80% decline in the death rate of cardiac patients receiving the supplement. 91 Chondroitin Sulfate is a mucopolysaccharide. Many mucopolysaccharide. Normally circulate in the blood and have been found to lower cholesterol and to retard the aging and degenerating of the arteries.92

Coenzyme Q-10 has just recently been made available in the U.S. after having been used in Japan for many years. However, it is an American, Dr. Karl Folkers of Texas, who has completed such massive research on this natural body enzyme. Studies have shown this vital energy-producing enzyme is often deficient in cardiac patients. 93 Co Q-10 has been found to bring improvement in all forms of cardiac malfunctions when taken in large enough doses on a daily basis. 94

DONG QUAI is an herb which grows throughout most of the world. However, it is in Asia that it has long been used for health purposes. Recent studies have shown that this herb contains various forms of natural coumarins, which create a vasodilating effect, which lowers blood pressure. This is achieved through its calcium-blocking abilities. It has also been found to have anti-arrhythmia characteristics. 95

HAWTHOREN BERRY is an herb which for more than 100 years has been used as an extremely effective support for the heart. It was said to relieve high blood pressure, edema, poor valve function, rapid and irregular heart beat, and lung congestion after all else had failed - and never once did it do harm no mater how much was taken. All of these statements were made 75 years ago in the Journal of the AMA.97

GERMANIUM SESQUIODISE: In use for the past several years in Japan, this organically-bounded mineral carries three atoms of oxygen, which can be released in the tissues. Drs. S. Tomizawa and associates reported in 1978 on research which demonstrated the germanium compounds have the ability to lower blood pressure and increase cardiac efficiency. 102

CONCLUSION:

One hundred two scientific references have been cited in reviewing the key nutrients used in the "LIFETIME" Formula. They clearly indicated that nutritional supplements often can play a major role in creating a healthy heart and vascular system - even after year of neglect. Just think, each of the results cited here was obtained when only one nutrient was used! Imagine what might be possible when all of them are used in one carefully balanced formula!

"LIFETIME" FORMULA AS A DAILY MAINTENCE. This Formula also offers a powerful blend of synergistic nutrients carefully balanced to provide optimum daily nutritional support, thus creating the ideal daily maintenance supplement for exceptional health and longevity for people of all ages!

WARNING: No one should ever quit taking reduce heart or blood pressure medication unless being advised to do so by their physician. To do otherwise could be fatal. Some medications are easy to get on, but very difficult to get off.

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